Evidence map›Paper›PMID 42109862›Full record

ArticleiScience2026

MAP3K1 integrates RhoA/ROCK signaling to regulate epithelial morphogenesis.

Bo Xiao, Maureen Mongan, Young-Bum Kim, Ying Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bo XiaoDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Maureen MonganDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Young-Bum KimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Ying XiaDepartment of Environmental and Public Health Sciences, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological processes rely on the interplay between genetic and environmental cues, yet the mechanisms underlying gene-gene (G×G) and gene-environment (G×E) interactions remain poorly understood. Using mouse embryonic eyelid closure as an experimentally tractable model, we extend the established S1PR-MAP3K1-JNK signaling axis by identifying a RhoA-ROCK branch as a functionally integrated component of the MAP3K1 network. These pathways converge on paxillin phosphorylation and c-Jun activation, coupling cytoskeletal remodeling with AP-1-dependent transcriptional responses. TurboID-based proximity proteomics identifies Gβ2 and RhoGEF1/5 as candidate intermediates linking MAP3K1 to S1PR and RhoA. Genetic analyses reveal that

Indexed as

Biological morphologyTranscriptomics

Identifiers

PMID42109862
PMCPMC13156762

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.