Longitudinal changes in coagulation-fibrinolysis in patients with traumatic brain injury within seven days after injury.

Xinlong Dong, Nanyu Yao, Limin Zhang, Guanghui Zheng, Yutong Zhao, Weiming Liu

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Xinlong DongDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Nanyu YaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Limin ZhangLaboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Guanghui ZhengLaboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Yutong ZhaoBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Weiming LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI)-induced coagulopathy is associated with poor outcomes of patients, but its progression remains poorly understood. We longitudinally collected peripheral venous blood samples from patients with TBI 24 h, 3 days, and 7 days after injury, and analyzed the samples for conventional blood and conventional coagulation tests, thromboelastography, coagulation factor activity, platelet activity, and levels of extracellular vesicles through laboratory tests. By detecting longitudinal changes in the coagulation-fibrinolysis, we found that TBI patients were in a state of hyperfibrinolysis within 24 h after injury, but transitioned to a hypercoagulable state on the 7

Indexed as

cardiovascular medicinehealth sciencesmedical specialtymedicine

Identifiers

PMID42109853

DOI10.1016/j.isci.2026.115443

PMCPMC13156692

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.