Evidence map›Paper›PMID 42109852›Full record

ArticleiScience2026

Age modulates estradiol's dual role in hepatocellular carcinoma recurrence after ablation: A prospective observational study.

Xudong Gao, Jingfeng Bi, Shuwen Yang, Zhongyi Zhang, Na Liu, Wei Wu, Kun Yan, Jinghui Dong, Changchun Liu, Yun Zhu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xudong GaoDepartment of Hepatology, the 5th Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Jingfeng BiDepartment of Infectious Disease, The 5th Medical Center of PLA General Hospital, Beijing 100039, China.
Shuwen YangDepartment of Infectious Disease, The 5th Medical Center of PLA General Hospital, Beijing 100039, China.
Zhongyi ZhangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Na LiuThe Fourth Retired Veteran Cadre's Sanatorium, Beijing 100166, China.
Wei WuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Kun YanKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Jinghui DongRadiology Department, The 5th Medical Center of PLA General Hospital, Beijing 100039, China.
Changchun LiuRadiology Department, The 5th Medical Center of PLA General Hospital, Beijing 100039, China.
Yun ZhuDepartment of Hepatology, the 5th Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Jiagang HuangDepartment of Hepatology, the 5th Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Zhen ZengDepartment of Hepatology, the 5th Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
MinHua ChenKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between estrogen and hepatocellular carcinoma (HCC) remains controversial. This study explored estradiol (E2)'s effect on HCC recurrence post-minimally invasive treatment and age's critical modifying role. 247 male HCC patients were prospectively enrolled, underwent radiofrequency ablation, and followed up for 36 months. Confounding factors were analyzed via cubic spline regression Cox model, with hierarchical analysis for age-specific effects. E2 and age showed a nonlinear correlation with HCC recurrence, with age identified as a confounding factor for E2. The cutoff values were 53/67 years (age) and 42 pg/ml (E2). For patients <53 years, E2 ≥42 pg/mL was linked to a significantly lower cumulative recurrence rate (CRR,

Indexed as

oncologypublic health

Identifiers

PMID42109852
PMCPMC13156675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.