ArticleImmune network2026
Cigarette Smoke Induces the Pro-inflammatory Response of Lung Macrophages via Activation of the IL-33/ST2-Dependent Pathway.
Article in Immune network, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Cigarette smoke broadly affects the immune system, but the mechanisms by which it disrupts lung innate immunity and impairs macrophage-mediated homeostasis in healthy individuals remain unclear. This study investigates airway inflammation induced by chronic cigarette smoke extract (CSE) exposure by profiling pulmonary macrophages. CSE was generated by bubbling smoke from ten Marlboro cigarettes into 10 ml PBS to obtain 100% CSE, and C57BL/6 mice received 10% CSE intranasally 3 times per week for 4 wk. Chronic CSE exposure induced neutrophilic airway inflammation and augmented pulmonary Th17 and Th1 responses. Among macrophage subsets, CSE exposure promoted the expansion of CD11c
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