ReviewAlzheimer's & dementia (Amsterdam, Netherlands)
Peripheral oxidative stress related biomarkers in Alzheimer's disease: A systematic review of their implications for diagnosis and disease monitoring.
Review in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which oxidative stress drives amyloid beta accumulation and neuronal damage. Fluid-based oxidative stress-related biomarkers offer promising, minimally invasive platforms for early detection, with this review evaluating their diagnostic potential. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search of PubMed, Scopus, and Google Scholar identified human studies published between 2000 and 2025 examining fluid-based oxidative stress-related biomarkers in individuals with AD. Elevated lipid peroxidation markers (malondialdehyde, 4-hydroxynonenal, and 1-palmitoyl-2-[5'-oxovaleroyl]-sn-glycero-3-phosphocholine) were consistently linked to AD and cognitive decline. Antioxidant enzymes (superoxide dismutase, glutathione [GSH] peroxidase, and catalase) showed reductions, while GSH and the GSH:oxidized GSH ratio emerged as robust indicators of redox imbalance in AD. Urinary 8-hydroxyguanosine demonstrated compartment-specific sensitivity. Altered trace elements (low selenium, iron, uric acid, and high copper) reflected systemic disruption in AD. Peripheral oxidative stress-related biomarkers offer scalable, minimally invasive avenues for AD diagnosis and monitoring, supporting improved clinical decision making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.