ReviewFrontiers in allergy2026
The testosterone paradox in asthma.
Review in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
1 author.
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Abstract
Asthma and an excessive response to inhaled methacholine, commonly called hyperresponsiveness, are intimately linked. Therefore, factors increasing the methacholine response are expected to contribute to asthma as well. However, this is clearly not the case for testosterone, the predominant sex hormone in males. While testosterone increases the methacholine response, it is rather protective in asthma and experimental asthma. These incompatible observations are referred herein as the 'testosterone paradox', and the chase is now on to unravel its underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.