Evidence map›Paper›PMID 42109475›Full record

ArticleFrontiers in pediatrics2026

Circadian disruption associated with nighttime light exposure contributes to airway epithelial remodeling via

Qiaoyan Dai, Fangxun Zhou, Tieshuai Liu, Hanghao Ma, Wei Zhou, Qidong Ye, Yingshuo Wang, Minfei Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiaoyan DaiDepartment of Pediatrics, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Fangxun ZhouDepartment of Computer Science, Zhejiang University, Hangzhou, China.
Tieshuai LiuDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hanghao MaDepartment of Intensive Care Unit, Ningde People's Hospital, Ningde, China.
Wei ZhouNational Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qidong YeDepartment of Pediatrics, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Yingshuo WangNational Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Minfei HuDepartment of Pediatrics, The First Affiliated Hospital of Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Childhood asthma is a common inflammatory airway disease, and its occurrence is influenced by environmental factors. Artificial light at night (ALAN) can disrupt circadian rhythms, but its relationship with childhood asthma remains unclear. To evaluate the association between ALAN and childhood asthma, and to investigate the role of the circadian clock gene in this relationship. Method: The study combined multiple approaches: an epidemiological analysis of asthma prevalence and urban ALAN levels in China; a pediatric asthma clinical study assessing nighttime light exposure, circadian disruption, and lung function; Mendelian randomization to test for a causal link between circadian disruption and asthma, and multi-omics plus experimental models to evaluate the function of Results: ALAN exposure in Chinese cities has increased and was identified by AutoGluon modeling as a significant environmental risk factor for childhood asthma. In a pediatric asthma cohort, excessive nighttime light exposure was strongly associated with circadian rhythm disruption ( Conclusions: Circadian disruption associated with nighttime light exposure may contribute to airway epithelial proliferation and remodeling via

Indexed as

artificial light at night (ALAN)childhood asthmacircadian rhythmimmune inflammationTIMELESS gene

Identifiers

PMID42109475
PMCPMC13149469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.