ArticleBioinformation2026
Correlation of disease activity in vitiligo patients and its relation with HSP70 expression.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
An acquired pigmenting disorder, vitiligo, occurs worldwide with a prevalence of 0.5-2% and in India with 0.25%-4%. Stress-related pathways are involved may contribute to autoimmune melanocyte loss and HSP 70 (a stress-response molecular chaperone with immune- modulatory effects) may be a key link between stress and disease activity. In this case-control study, 40 vitiligo patients and 40 age and sex-matched controls underwent skin biopsies (lesional and non-lesional skin in patients; normal skin in controls) and HSP 70 mRNA expression was quantified using real-time PCR; patients were also grouped as highly active, moderately active or inactive based on clinical activity. Lesional vitiligo skin showed significantly higher HSP 70 expression than non-lesional skin and control skin (both P < 0.001), with higher mean levels in active compared with inactive vitiligo, while no association was found with age, sex or disease duration-supporting a role of HSP 70-related stress mechanisms in vitiligo pathogenesis and activity.
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