Evidence map›Paper›PMID 42109364›Full record

ArticleBioinformation2026

Serum fetuin A and cystatin B as biomarkers among autism spectrum disorder patients in central India.

Sameeksha Luthra, Niranjan Gopal, Urmila Dahake, Dnyanesh Amle, Jyoti E John, Roshan Takhelmayum, Utsav Haldar, Jancy Jose, Chandrasekaran Kirubhanand

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sameeksha LuthraDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Niranjan GopalDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Urmila DahakeDepartment of Paediatrics, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Dnyanesh AmleDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Jyoti E JohnDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Roshan TakhelmayumDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Utsav HaldarDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Jancy JoseDepartment of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Chandrasekaran KirubhanandDepartment of Anatomy, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) remains underdiagnosed in low- and middle-income countries due to reliance on subjective behavioural assessments and lack of validated objective biomarkers for early detection. Therefore, it is of interest to investigate the potential of two serum biomarkers, Fetuin-A and Cystatin B, as objective diagnostic indicators for ASD in 60 children from Central India (30 with ASD, 30 controls). While Fetuin-A showed a non-significant trend of elevation in the ASD group, Cystatin B levels were found to be significantly elevated in the ASD subjects compared to the neurotypical controls. ROC analysis demonstrated moderate diagnostic potential for both, with Cystatin B showing a higher Area under the Curve (AUC) of 69.5%. Thus, Cystatin B is a promising serum biomarker that could supplement current diagnostic tools for the early and accurate identification of ASD.

Indexed as

Autism spectrum disorder (ASD)BiomarkersCystatin BEnzyme-Linked Immunosorbent Assay (ELISA)Fetuin-AIndiaNeuroinflammationPaediatric NeurodevelopmentROC Analysis

Identifiers

PMID42109364
PMCPMC13150171

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