ArticleNucleic acids research2026
RegRegSEA: a web server for regulatory region set enrichment analysis of epigenomic data.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Interpreting genome-wide epigenomic experiments, such as DNA methylation profiling and chromatin accessibility assays, requires tools that can identify which regulatory programs underlie coordinated changes across genomic regions. Without this regulatory context, lists of differential regions remain largely descriptive and difficult to interpret mechanistically. Existing approaches either apply hard significance cutoffs that discard moderate but biologically meaningful signals, or rely on gene-centric annotations that neglect enhancers and intergenic space, introducing bias into the interpretation. RegRegSEA addresses both shortcomings by adapting the Gene Set Enrichment Analysis framework directly to genomic coordinates. The server accepts a standard differential analysis table, ranks all tested intervals by a signed statistic, and computes enrichment scores against curated regulatory databases including transcription factor binding site collections. Results are returned as an interactive, publication-ready report featuring dynamic visualizations of enrichment profiles and regulatory annotations, along with downloadable leading-edge regions for downstream analyses. We demonstrate the utility of this approach through re-analysis of Down syndrome brain methylation data and chromatin accessibility in ageing mouse liver. The server is freely available at https://web.ccb.uni-saarland.de/regregsea/ and open to all users with no login required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.