ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2026
Turning as a single and dual task-associations with Alzheimer's and vascular pathologies in cognitively healthy older people.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTurning performance is an important and challenging motor activity, with potential relevance in several brain diseases. This study aimed to determine how Alzheimer's and vascular pathologies are associated with turning (360° while standing and 180° while walking), both as a single task and during dual-tasking in cognitively healthy older people.
methodsCognitively healthy older people (n = 297, mean age 77.7 years, 61.6% women) were included. A 180° turn was assessed using a wearable sensor; a 360° turn was assessed both clinically and using a sensor. Dual-tasking included a simultaneous subtraction task. Alzheimer's pathologies (Aβ and tau) were assessed using positron emission tomography (PET). Vascular pathology (white matter hyperintensities (WMH)) was assessed using magnetic resonance imaging (MRI). Logistic and linear regression analyses were used.
resultsAβ and tau pathologies were significantly associated with being unstable while dual-tasking and turning 360°. When including both Aβ and tau in the model, only tau remained significantly associated with being unstable (OR 22.42, 95% CI, 1.43, 349.88, p = .027). WMH were associated with impaired turning as a single task, that is, an increased turn duration (360°) and a decreased peak angular velocity (180°: B -1.27, 95% CI, -2.33, -0.21, p = .018).
conclusionsThis study suggests that early Alzheimer's pathologies are associated with an instability while turning 360° and dual-tasking, whereas WMH seem to be associated with impaired turning as a single task in cognitively healthy older people. Turning assessments seem promising for investigating motor aspects in very early stages of Alzheimer's disease and vascular brain disease.
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