Evidence map›Paper›PMID 42108953›Full record

ArticlePsychological medicine2026

Insomnia severity impact dynamic connectivity and modulate connectivity-cognitive links in major depressive disorder.

Weijie Bao, Yingxue Gao, Hailong Li, Zilin Zhou, Yidan Wang, Xinyue Hu, Qiyong Gong, Xiaoqi Huang

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In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Weijie BaoDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yingxue GaoDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Hailong LiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Zilin ZhouDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yidan WangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Xinyue HuDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Qiyong GongDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Xiaoqi HuangDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, https://ror.org/007mrxy13West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-8686-5010

Funding

National Natural Science Foundation of China 82372080
6 · The paper itself

Abstract

backgroundInsomnia is common in major depressive disorder (MDD), and varying severity of insomnia may be associated with distinct neural alterations in MDD. Dynamic functional connectivity can capture time-varying brain network interactions and may help disentangle insomnia-related mechanisms in MDD.

methodsWe recruited 203 drug-naïve adult MDD patients, divided into high- (HI-MDD,

resultsWhile static FNC revealed no significant group difference, dynamic analysis identified distinct connectivity states between two groups. Compared to HCs, HI-MDD displayed more frequent occurrence of state I and less of state IV, a pattern was absent in LI-MDD. Both MDD groups showed increased default mode network (DMN)-lateral ventral attention network (VAN) connectivity in states I and II, accompanied by decreased dorsal attention network-cerebellar/DMN connectivity in state I relative to HCs. Compared with LI-MDD, HI-MDD exhibited enhanced DMN-medial VAN connectivity in state II, along with increased DMN connectivity with visual and sensorimotor networks in state I, suggesting insomnia-related changes. In addition, we identified insomnia-related memory deficits and depression-related processing speed impairment in MDD. Insomnia significantly moderated the association between altered DMN-lateral VAN connectivity in state I and logical memory impairment in MDD.

conclusionsThese findings suggest that insomnia severity in MDD is associated with distinct temporal patterns of brain network alterations beyond shared depression-related changes and moderate cognitive functions in MDD.

Indexed as

BrainCognitionConnectomeDefault Mode NetworkMajor Depressive DisorderNerve NetSleep Initiation and Maintenance DisordersAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSeverity of Illness Indexcognitiondepressiondynamicfunctional network connectivityinsomnia

Identifiers

PMID42108953
PMCPMC13161810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.