Evidence map›Paper›PMID 42108858›Full record

ArticleBiology open2026

Profiling cell proliferation after whole-genome duplication in human cells.

Guang Yang, Masaya Inoko, Kaito Ogura, Sumire Ishida-Ishihara, Yuki Tsukada, Akira Funahashi, Masanao Sato, Ryota Uehara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guang YangGraduate School of Life Science, Hokkaido University, 001-0021, Sapporo, Japan.
Masaya InokoGraduate School of Life Science, Hokkaido University, 001-0021, Sapporo, Japan.
Kaito OguraGraduate School of Life Science, Hokkaido University, 001-0021, Sapporo, Japan.
Sumire Ishida-IshiharaFaculty of Advanced Life Science, Hokkaido University, 001-0021, Sapporo, Japan.
Yuki TsukadaDepartment of Biosciences and Informatics, Keio University, Yokohama, 223-8522, Japan.
Akira FunahashiDepartment of Biosciences and Informatics, Keio University, Yokohama, 223-8522, Japan.
Masanao SatoGraduate School of Agriculture, Hokkaido University, 060-8589, Sapporo, Japan.
Ryota UeharaGraduate School of Life Science, Hokkaido University, 001-0021, Sapporo, Japan.ORCID 0000-0001-8240-7928

Funding

Akiyama Life Science FoundationAkiyama Life Science Foundation N/ADaiichi Sankyo Foundation of Life ScienceDaiichi Sankyo Foundation of Life Science N/AHoansha FoundationHoansha Foundation N/AHokkaido UniversityJSPS KAKENHI JP19H03219JSPS KAKENHI JP19H05413JSPS KAKENHI JP19KK0181JSPS KAKENHI JP19KK0181, JP19H05413, JP19H03219, JPJSBP120193801, JP21K19244, JP22H04926, JP24K21956, JP24KK0139, and JP24K02017JSPS KAKENHI JP21K19244JSPS KAKENHI JP22H04926JSPS KAKENHI JP22KJ0138JSPS KAKENHI JP22KK0110JSPS KAKENHI JP22KK0110, and JP23K19360JSPS KAKENHI JP23K19360JSPS KAKENHI JP24K02017JSPS KAKENHI JP24K21956JSPS KAKENHI JP24KK0139JSPS KAKENHI JPJSBP120193801JSPS KAKENHI JST SPRING JPMJSP2119Kato Memorial Bioscience FoundationKato Memorial Bioscience Foundation N/APrincess Takamatsu Cancer Research FundPrincess Takamatsu Cancer Research Fund N/ASumitomo Electric Group CSR FoundationSumitomo Electric Group CSR Foundation N/ATerumo Life Science Foundationthe Orange Foundationthe Orange Foundation N/Athe Smoking Research Foundationthe Smoking Research Foundation N/Athe Terumo Life Science Foundation N/A
6 · The paper itself

Abstract

Though whole-genome duplication (WGD) contributes to cancer progression, the mechanism of post-WGD cell proliferation remains unclear. Here, using 6-day live-imaging, we analyzed the proliferation dynamics of more than 150 post-WGD HCT116 cell lineages. A quantitative comparison of mitotic patterns and cell fates between proliferative and non-proliferative lineages revealed that multipolar chromosome segregation in early mitosis is a potential key factor limiting the proliferative capacity of post-WGD progenies. Multipolar chromosome segregation correlated with suppressed post-WGD cell viability, particularly when accompanied by drastic chromosome loss or when it repeatedly occurred. Tracing proliferative lineages elucidated that they proliferated mainly by imposing the risk of multipolar chromosome segregation on one of two sub-lineages that formed after the first bipolar division. Meanwhile, a considerable proportion of proliferative lineages consisted entirely of progeny of early multipolar chromosome segregation events. Our results highlight key cellular events that determine the proliferation dynamics and diversity of post-WGD progenies, providing a fundamental reference for understanding WGD-associated biological processes.

Indexed as

Cell ProliferationGene DuplicationGenome, HumanCell LineageChromosome SegregationHCT116 CellsHumansMitosisCell deathCell lineage trackingChromosome instabilityMitosis

Identifiers

PMID42108858
PMCPMC13267767

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.