Evidence map›Paper›PMID 42108688›Full record

ArticleChemistry & biodiversity2026

Discovery and Evaluation of Spirofluorenes Based on Imidazolidinedione as Insecticidal Agent Leads.

Sameera N Al-Ghamdi, Fatemah M Asiri, Ibtesam Y Mashnoy, Amal A Alageel, Ohoud J Alotaibi, Nujud H Alqahtani, Mohamed A Gad, Antar A Abdelhamid

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sameera N Al-GhamdiDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha, Saudi Arabia.
Fatemah M AsiriChemistry Department, College of Science & Arts, Najran University, Najran, Saudi Arabia.
Ibtesam Y MashnoyChemistry Department, College of Science & Arts, Najran University, Najran, Saudi Arabia.
Amal A AlageelChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Ohoud J AlotaibiDepartment of Chemistry Sciences, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Nujud H AlqahtaniDepartment of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia.
Mohamed A GadResearch Institute of Plant Protection, Agricultural Research Center, Giza, Egypt.ORCID https://orcid.org/0000-0001-7850-7520
Antar A AbdelhamidDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eight imidazolidine-2,4-dione derivatives based on spirofluorenes (3-10) have been investigated; these include differences in the aliphatic chain's length and functional groups. Spiro[fluorene-9,4'-imidazolidine]-2',5'-dione 1 was alkylated with different ethyl halo ester to create ethyl 3-(2',5'-dioxospiro[fluorene-9,4'-imidazolidin]-1'-yl)alkanoate 3-6. The corresponding alkanoic acids 7-10 were obtained by hydrolyzing the esters 3-6 with potassium hydroxide in methanol and then acidifying the mixture. Spectral and elemental analysis were employed to regulate the structure and purity of materials 3-10. The findings demonstrated that each product tested exhibited variable levels of insecticidal effective against the larval instars of Spodoptera littoralis. With an LC

Indexed as

Drug DiscoveryFluorenesImidazolidinesInsecticidesSpiro CompoundsSpodopteraAnimalsDose-Response Relationship, DrugLarvaMolecular StructureStructure-Activity RelationshipFluorenesImidazolidinesInsecticidesSpiro CompoundsAlkylationFureneneHydrolysisImidazolidinedioneInsecticidal

Identifiers

PMID42108688
PMCPMC13380997

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.