Evidence map›Paper›PMID 42108674›Full record

GuidelineNeurogastroenterology and motility2026

A Clinical Practice Update for the Management of Patients With Disorders of Gut-Brain Interaction and Altered Food Intake Behavior.

Ayesha Shah, Nicholas J Talley, Simon R Knowles, Kerith Duncanson, Natasha Koloski, Jason P Connor, Andrew S Day, Basil Almehdawy, Chamara Basnayake, Rebecca Burgell and 15 more

Abstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ayesha ShahDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Nicholas J TalleyAustralian Gastrointestinal Research Alliance and NHMRC CRE in Transforming Gut Health, Brisbane, Australia.
Simon R KnowlesSchool of Health Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Kerith DuncansonDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Natasha KoloskiDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Jason P ConnorFaculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Andrew S DayDepartment of Paediatrics and Child Health, University of Otago Christchurch, Christchurch, New Zealand.
Basil AlmehdawyFaculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Chamara BasnayakeDepartment of Gastroenterology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
Rebecca BurgellBayside Health and Monash University, Melbourne, Victoria, Australia.
Sharon CareyFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Charles CockDept Gastroenterology & Hepatology, Flinders Medical Centre, Southern Adelaide Local Health Network & Flinders University, Adelaide, South Australia, Australia.
Charlotte DakerDepartment of Gastroenterology, North Shore Hospital, Auckland, New Zealand.
Vishal KaushikDepartment of Gastroenterology and Hepatology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Dan KentConsumer Representative, Queensland Clinical Network, Brisbane, Queensland, Australia.
Trina KellarFaculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Katherine LaneQueensland Eating Disorder Service, Metro North Mental Health Service, Brisbane, Queensland, Australia.
Neal MartinDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Allison MalcolmFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Kate Elizabeth MurphyQueensland Eating Disorder Service, Metro North Mental Health Service, Brisbane, Queensland, Australia.
Gemma SharpDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Caroline TuckSchool of Health Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Michael JonesAustralian Gastrointestinal Research Alliance and NHMRC CRE in Transforming Gut Health, Brisbane, Australia.
Nikhil ThaparFaculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Gerald HoltmannDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Funding

National Health and Medical Research Council APP1084544National Health and Medical Research Council APP170993
6 · The paper itself

Abstract

backgroundDisorders of Gut-Brain Interaction (DGBI) impact as many as one in three individuals at some stage of their lives. Clinically, patients with DGBI may present with meal-related symptoms that progressively lead to altered food intake behaviors, resulting in subsequent weight loss and nutritional deficiencies. These patients often experience psychological distress and multi-system co-morbidities. This distinct subgroup can be referred to as DGBI-induced altered food intake behavior (DGBI-AFIB) and needs to be differentiated from the eating disorder defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition: Avoidant/Restrictive Food Intake Behavior. PURPOSE: There is currently no expert consensus on the management of DGBI-AFIB. To address this gap, a multidisciplinary, multi-society expert panel employed a Delphi process to develop evidence-based management guidelines for DGBI-AFIB. The group formulated and evaluated 23 statements using the GRADE system. Experts agreed that a diagnosis of DGBI-AFIB should be considered when gastrointestinal symptoms meet the Rome criteria for DGBI, are aggravated by food intake, and subsequently result in altered (reduced) food intake, leading to a significant (unintended) reduction in body weight. To establish a positive diagnosis of DGBI-AFIB, relevant differential diagnoses need consideration, including organic causes/eating disorders. A multidisciplinary team approach is key to management. Treatment must align with established DGBI principles and consider each patient's specific challenges. Enteral or parenteral feeding should only be pursued in patients with life-threatening nutritional deficiencies after all oral nutrition approaches have failed. Future research is essential to elucidate the epidemiological characteristics and risk factors for DGBI-AFIB, thereby enhancing long-term management.

Indexed as

Brain-Gut AxisEatingFeeding and Eating DisordersFeeding BehaviorGastrointestinal DiseasesHumansaltered food intake behavioravoidant/restrictive food intake disorderdisorders of gut‐brain interactioneating disordersfunctional dyspepsia

Identifiers

PMID42108674
PMCPMC13180447

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.