Evidence map›Paper›PMID 42108671›Full record

ArticleChemistry & biodiversity2026

Natural Products in Gambeya lacourtiana (Sapotaceae): Identification, In Vitro Cytoxicity, and Deep Learning-Based Pharmacokinetic Prediction.

Marcelle O Ngangoue, Smith B Babiaka, Godloves Fru Chi, Conrad V Simoben, Armelle T Mbaveng, Japheth O Ombito, Bathelemy Ngameni, Victor Kuete, Thomas Efferth, Bonaventure T Ngadjui

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcelle O NgangoueDepartment of Organic Chemistry, Faculty of Science University of Yaoundé 1, Yaoundé, Cameroon.
Smith B BabiakaDepartment of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon.ORCID https://orcid.org/0000-0002-4476-5860
Godloves Fru ChiDepartment of Chemistry, Faculty of Science, University of Botswana, Gaborone, Botswana.ORCID https://orcid.org/0000-0002-1484-3995
Conrad V SimobenStructural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-5958-6961
Armelle T MbavengDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0003-4178-4967
Japheth O OmbitoDepartment of Chemistry, Faculty of Science, University of Botswana, Gaborone, Botswana.ORCID https://orcid.org/0000-0001-9973-0190
Bathelemy NgameniDepartment of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.ORCID https://orcid.org/0000-0002-6045-0981
Victor KueteDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0002-1070-1236
Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.ORCID https://orcid.org/0000-0002-2637-1681
Bonaventure T NgadjuiDepartment of Organic Chemistry, Faculty of Science University of Yaoundé 1, Yaoundé, Cameroon.ORCID https://orcid.org/0000-0002-3668-4593

Funding

Alexander von Humboldt FoundationNetwork of Analytical and Bioassay Services in Africa (NABSA) 032015
6 · The paper itself

Abstract

Cancer is a leading cause of death worldwide, and chemotherapy is facing challenges ranging from side effects, selectivity, and resistance. Molecules from nature are a prolific source of anticancer molecules. This study aimed to discover new anticancer molecules from Gambeya lacourtiana stem bark extract using in vitro assays. Complete assignment of the NMR data of 3, 5, 7, 3', 5'-pentahydroxy-4'-methoxyflavane or 4'-methoxyepigallocatechin (1) isolated from the stem bark of G. lacourtiana along with (-)-epicatechin (2), β-amyrin pentanoate (3), α-amyrin acetate (4), lupeol acetate (5), taraxerol (6), 28-hydroxyl-3β-amyrin (7), euscaphic acid (8), betulinic acid (9), chondrillasterol (10), and 3-O-β-D-glucopyranosyl chondrillasterol (11) was achieved. Structures were elucidated by the interpretation of their NMR and spectrometric data in conjunction with literature data. In vitro cytotoxicity carried out on isolates toward CCRF-CEM revealed only compound 1 to be moderately cytotoxic (IC

Indexed as

Antineoplastic Agents, PhytogenicBiological ProductsAnimalsAntioxidantsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructurePlant BarkPlant ExtractsStructure-Activity RelationshipAntineoplastic Agents, PhytogenicAntioxidantsBiological ProductsPlant ExtractscatechinscytotoxicityGambeya lacourtianain silico pharmacokineticsNMR datatriterpenes

Identifiers

PMID42108671
PMCPMC13376693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.