Evidence map›Paper›PMID 42108579›Full record

ArticleJournal of chemical information and modeling2026

Decoding Prolonged Residence Time of 5-HT

Szymon K Kordylewski, Kinga Kurowska, Krystyna Nędza, Dorota Satała, Ryszard Bugno, Sabina Podlewska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Szymon K KordylewskiMaj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
Kinga KurowskaMaj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
Krystyna NędzaMaj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
Dorota SatałaMaj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
Ryszard BugnoMaj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.
Sabina PodlewskaMaj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland.ORCID 0000-0002-2891-5603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lifetime of a ligand-receptor complex has been suggested to play an important role in compound activity and sustained pharmacological action. However, due to the multitude of other factors considered during optimization, this aspect is often neglected in the early stages of drug design and development. Consequently, data on ligand residence time (RT) remain limited, and the molecular determinants underlying prolonged binding are not fully understood. In this study, we focused on ritanserin, a known 5-HT

Indexed as

Receptor, Serotonin, 5-HT2ARitanserinSerotonin 5-HT2 Receptor AntagonistsHumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingLigandsReceptor, Serotonin, 5-HT2ARitanserinSerotonin 5-HT2 Receptor Antagonists

Identifiers

PMID42108579
PMCPMC13308886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.