Evidence map›Paper›PMID 42108566›Full record

ArticlePest management science2026

Antifungal activity and potential mechanisms of two new bafilomycin analogues from Streptomyces sp. TH30 against tomato early blight.

Yunfei He, Jing Miao, Xiaoyu Yan, Chuntong Chen, Shaoyong Zhang, Jidong Wang, Huan Qi, Yi Wu, Yongsheng Gao, Ruijun Wang

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Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yunfei HeZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.ORCID https://orcid.org/0009-0006-4966-3907
Jing MiaoZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Xiaoyu YanZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Chuntong ChenZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Shaoyong ZhangZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Jidong WangZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Huan QiZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Yi WuZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Yongsheng GaoZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.
Ruijun WangZhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Huzhou University, Huzhou, China.

Funding

Huzhou UniversityScience and Technology Department of Zhejiang Province
6 · The paper itself

Abstract

backgroundTomato early blight, which is caused by the pathogenic fungus Alternaria solani, poses a serious threat to global tomato cultivation and yield. This situation underscores the urgent need for innovative, eco-friendly biocontrol approaches.

resultsIn the present work, a strain designated as Streptomyces sp. TH30 was isolated from tomato rhizosphere soil. This strain exhibited notable antagonistic activity against A. solani, suppressing its mycelial growth by 71.3% in a dual-culture assay. Chemical examination of the TH30 fermentation broth yielded two new bafilomycin analogues, bafilomycin H (1) with a unique furan ring group and 19-O-methylhygrolidin (2), together with the known compound halichomycin (3). Their structures were unequivocally established through integrated spectroscopic analyses (1D/2D NMR, HRESIMS) and comparison with previously reported data. Compounds 1 and 2 displayed pronounced antifungal potency against A. solani, with EC

conclusionThese findings demonstrate that bafilomycin analogues from Streptomyces sp. TH30 represent promising candidates for the development of novel biofungicides against tomato early blight. © 2026 Society of Chemical Industry.

Indexed as

AlternariaAntifungal AgentsFungicides, IndustrialMacrolidesPlant DiseasesSolanum lycopersicumStreptomycesAntifungal AgentsFungicides, IndustrialMacrolidesAlternaria solanisecondary metabolitesSolanum lycopersicumStreptomyces sp.tomato early blight

Identifiers

PMID42108566
PMCPMC13453253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.