Evidence map›Paper›PMID 42108558›Full record

ArticleExperimental dermatology2026

Melatonin Regulates Arylhydrocarbon Receptor Mediated UVR-Induced Processes Related to Inflammation, Skin Aging and Carcinogenesis in Human Ex Vivo Skin.

Katharina Pustelnik, Teresa Burner, Wolfram Hoetzenecker, Tobias W Fischer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katharina PustelnikDepartment of Dermatology and Venereology, Kepler University Hospital Linz and Johannes Kepler University Linz, Linz, Austria.ORCID https://orcid.org/0009-0001-8122-4385
Teresa BurnerDepartment of Dermatology and Venereology, Kepler University Hospital Linz and Johannes Kepler University Linz, Linz, Austria.
Wolfram HoetzeneckerDepartment of Dermatology and Venereology, Kepler University Hospital Linz and Johannes Kepler University Linz, Linz, Austria.
Tobias W FischerDepartment of Dermatology and Venereology, Kepler University Hospital Linz and Johannes Kepler University Linz, Linz, Austria.ORCID https://orcid.org/0009-0008-0635-3639

Funding

Medical Faculty of the Johannes Kepler University Linz
6 · The paper itself

Abstract

UV radiation (UVR), a known skin-stressor causing inflammation, aging and carcinogenesis, activates the arylhydrocarbon receptor (AhR) and downstream molecules which are crucially involved in photo-induced skin damage. In this study, the potent UV protector melatonin was investigated regarding UVR-mediated activation of AhR and downstream molecules including tumor suppressor p27, DNA double-strand break marker pH2AX, cyclooxygenase-2 (COX-2), mitogen-activated protein kinase-14 (MAPK14)/p38α, matrix metalloproteinase-2 (MMP2) and tissue inhibitor of matrix metalloproteinase-1 (TIMP1). They were studied in ex vivo human full-thickness skin irradiated with UVA/B light (0, 300 mJ/cm

Indexed as

Basic Helix-Loop-Helix ProteinsMelatoninReceptors, Aryl HydrocarbonSkinSkin AgingUltraviolet RaysCarcinogenesisCyclin-Dependent Kinase Inhibitor p27Cyclooxygenase 2HistonesHumansInflammationMatrix Metalloproteinase 2Skin NeoplasmsTissue Inhibitor of Metalloproteinase-1AHR protein, humanBasic Helix-Loop-Helix ProteinsCyclin-Dependent Kinase Inhibitor p27Cyclooxygenase 2H2AX protein, humanHistonesMatrix Metalloproteinase 2MelatoninMMP2 protein, humanPTGS2 protein, humanReceptors, Aryl HydrocarbonTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1agingarylhydrocarbon receptorcarcinogenesisinflammationmelatoninskinultraviolet radiation

Identifiers

PMID42108558
PMCPMC13158437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.