Evidence map›Paper›PMID 42108539›Full record

ArticleMolecular pain

Olfactory ensheathing cell transplantation targets macrophage extracellular traps and NKCC1 to alleviate pain after spinal cord injury.

Honghui Lei, Tao Liu, Fangyong Wang, Yang Yu, Sitong Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Honghui LeiSchool of Rehabilitation, Capital Medical University, Beijing, China.ORCID 0000-0001-9354-2762
Tao LiuSchool of Rehabilitation, Capital Medical University, Beijing, China.
Fangyong WangSchool of Rehabilitation, Capital Medical University, Beijing, China.ORCID 0000-0002-9499-8654
Yang YuSchool of Rehabilitation, Capital Medical University, Beijing, China.
Sitong SuSchool of Rehabilitation, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) triggers neuropathic pain through inflammatory secondary injury. Olfactory ensheathing cells (OECs) hold therapeutic promise, but their pain-relieving mechanisms are unclear. This study investigated whether OEC transplantation alleviates pain by modulating macrophage extracellular trap (MET) formation and Na

Indexed as

Cell TransplantationMacrophagesNeuralgiaOlfactory BulbSolute Carrier Family 12, Member 2Spinal Cord InjuriesAnimalsAntigens, CDFemaleMiceRatsRats, Sprague-DawleyRecovery of FunctionTumor Necrosis Factor-alphaAntigens, CDSlc12a2 protein, ratSolute Carrier Family 12, Member 2Tumor Necrosis Factor-alphadorsal root ganglionmacrophage extracellular trapsNa+–K+–Cl− cotransporter 1neuropathic painOlfactory ensheathing cellspinal cord injury

Identifiers

PMID42108539
PMCPMC13260965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.