ArticlePest management science2026
FM-3224: A potent triazolinone-based fungicide with broad-spectrum activity and computational support for putative dual-target binding.
Fanqi Meng, Yuandong Liu, Xiaowen Du, Lei Tian, Jing Zhang, Lixin Zhang
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In one paragraphArticle in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Fanqi Meng *National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.ORCID https://orcid.org/0009-0007-7872-8252 Yuandong Liu *National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Xiaowen DuNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Lei TianNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Jing ZhangNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Lixin ZhangNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Funding
National Natural Science Foundation of China 22277081Project of Education Department of Liaoning Province LJ232410149068Project of Education Department of Liaoning Province LJ232510149002
6 · The paper itselfAbstract
backgroundAsian soybean rust (ASR), caused by Phakopsora pachyrhizi, remains difficult to control because resistance has reduced the effectiveness of several major fungicide classes. In this study, we designed 1,2,4-oxadiazole derivatives bearing tetrazolinone or triazolinone fragments through fragment recombination and then explored the putative target-binding characteristics of the lead compound by computational methods.
resultsTwenty-four target compounds were synthesized and evaluated against P. pachyrhizi, Pseudoperonospora cubensis, Blumeria graminis, and Corynespora cassiicola. Among them, the triazolinone derivative B9 (FM-3224) showed the best overall performance. Against P. pachyrhizi, FM-3224 gave an EC
conclusionFM-3224 is a promising broad-spectrum lead compound. The biological results establish its strong fungicidal potential, whereas the docking and DFT analyses provide computational support for further investigation of its putative dual-target binding mode. © 2026 Society of Chemical Industry.
Indexed as
BasidiomycotaFungicides, IndustrialOxadiazolesTriazolesMolecular Docking SimulationPlant DiseasesFungicides, IndustrialOxadiazolesTriazoles1, 2, 4‐oxadiazoleAsian soybean rustfungicidal activityhistone deacetylase (HDAC)metyltetraprolemolecular docking
Identifiers
PMID42108517
PMCPMC13453161
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