Evidence map›Paper›PMID 42108481›Full record

ReviewCell & bioscience2026

Investigation of embryogenesis in a dish: the development and application of gastruloid models from pluripotent stem cells.

Kexin Lin, Hanyumo Chen, Yuxin Chen, Zhengyi Li, Peiqi Tian, Qizhe Shao, Honglin Yu, Di Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kexin LinCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Hanyumo ChenCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Yuxin ChenCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Zhengyi LiCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Peiqi TianCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Qizhe ShaoCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
Honglin YuCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. honglin.20@intl.zju.edu.cn.
Di ChenCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. dichen@intl.zju.edu.cn.ORCID http://orcid.org/0000-0002-9451-9721

Funding

Key Technologies Research and Development Program 2024YFA1108100National Natural Science Foundation of China 32270835Natural Science Foundation of Zhejiang Province Z22C129553
6 · The paper itself

Abstract

Gastrulation constitutes a critical phase of mammalian embryogenesis, during which the embryo undergoes morphological changes, germ layer determination, and body axes establishment, laying the foundation for subsequent embryonic development. However, due to the technical and ethical restrictions, embryo-based studies during the gastrulation period are limited in both the scope of scientific questions worth exploring and experimental tractability. Gastruloids, three-dimensional aggregates recapitulating embryos at the gastrulation stage, emerge as an in vitro platform to dissect the dynamics of this process. Owing to their high-throughput and tractable advantages, gastruloids hold broad application potential. In this review, we summarize current knowledge on mammalian embryogenesis and the insights from both mouse and human gastruloid models. We also discuss the current applications of gastruloids in embryogenesis, disease modeling, drug development, and regenerative medicine.

Identifiers

PMID42108481
PMCPMC13339701

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.