Evidence map›Paper›PMID 42108381›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Correlation between in vivo

Yishu Chao, Yuheng Chen, Trevor A Chadwick, Theresa M Harrison, Leonardo Iaccarino, Helmut Heinsen, Daniela Ushizima, Duygu Tosun, William J Jagust, Lea T Grinberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yishu ChaoDepartment of Neuroscience, University of California, Berkeley, Berkeley, California, USA.
Yuheng ChenMemory and Aging Center, Departments of Neurology and Pathology, University of California, San Francisco, California, USA.
Trevor A ChadwickDepartment of Neuroscience, University of California, Berkeley, Berkeley, California, USA.
Theresa M HarrisonDepartment of Neuroscience, University of California, Berkeley, Berkeley, California, USA.
Leonardo IaccarinoLilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana, USA.
Helmut HeinsenJosef-Schneider-Strasse 11, University of Würzburg, Würzburg, Germany.
Daniela UshizimaApplied Mathematics and Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Duygu TosunDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
William J JagustDepartment of Neuroscience, University of California, Berkeley, Berkeley, California, USA.
Lea T GrinbergMemory and Aging Center, Departments of Neurology and Pathology, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-6809-0618

Funding

Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progressionR01AG070826 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI GRINBERG, LEA TENENHOLZ, LIU, CHUNLEI · 2021 to 2025
$3.3M
Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's diseaseK01AG078443 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Theresa M. Harrison · 2022 to 2026
$656k
Avid Radiopharmaceuticals NCT02350634BrightFocus FoundationNIA NIH HHS K01 AG078443NIA NIH HHS R01 AG070826NIH HHS R01AG070826
6 · The paper itself

Abstract

introductionClinicopathological studies offer crucial interpretations of

methodsWe generated IHC maps for three AD-tau antibodies-AT8, AT100, and MC1-using two human brains histologically staged at Braak IV and VI. FTP-PET scans were acquired 6 and 10 weeks prior to death. Using region-wise and voxelwise methods, we correlated FTP-PET with IHC signals.

resultsOnly AT8 (p-tau Ser202/Thr205; neuronal and neuritic tau pathology) showed a notable correlation with FTP standardized uptake value ratios (SUVRs) in the Braak VI case (Spearman's rank correlation coefficient [r DISCUSSION: Although FTP signals correlate well with AT8-positive tau in the more advanced case, they underestimate the severity of MTL burden, potentially confounding assessments of tau-targeted therapies.

Indexed as

Alzheimer DiseaseBrainCarbolinesPositron-Emission Tomographytau ProteinsAgedAged, 80 and overFemaleHumansImmunohistochemistryMale7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleCarbolinestau Proteinscorrelationdigital immunohistochemistryflortaucipirneuropathologyPETtau

Identifiers

PMID42108381
PMCPMC13158160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.