Evidence map›Paper›PMID 42108360›Full record

Observational studyAnnals of surgical oncology2026

Robot-Assisted Versus Open Bladder Cuff Excision After Radical Nephroureterectomy: A Multicenter Study by the French Urothelial Cancer Committee.

Pierre-Etienne Gabriel, Thomas Seisen, Evanguelos Xylinas, Hugo Duquesne, Gautier Marcq, Igor Duquesne, Anne Sophie Bajeot, Jérémy Mercier, Benjamin Pradère, Louise Duffaut and 8 more

Abstract readComparative StudyMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Round up.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Pierre-Etienne GabrielDepartment of Urology, Université de Paris, APHP, Saint Louis Hospital, Paris, France. pierre.etienne.aphp@gmail.com.
Thomas SeisenSorbonne University, GRC 5 Predictive Onco-Uro, AP-HP, Urology, Hôpital Pitié-Salpetrière, Paris, France.
Evanguelos XylinasDepartment of Urology, Bichat Claude-Bernard Hospital, Assistance Publique-Hôpitaux de Paris Nord, University Paris Cité, Paris, France.
Hugo DuquesneUrology Department, Claude Huriez Hospital, CHU Lille, University Lille, CNRS, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, Inserm, France.
Gautier MarcqUrology Department, Claude Huriez Hospital, CHU Lille, University Lille, CNRS, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, Inserm, France.
Igor DuquesneDepartment of Urology, Hôpital Cochin, AP-HP, Université de Paris, Paris, France.
Anne Sophie BajeotUrology Department, Toulouse University Hospital, University of Toulouse UT3, Toulouse, France.
Jérémy MercierUrology Department, Toulouse University Hospital, University of Toulouse UT3, Toulouse, France.
Benjamin PradèreUROSUD Urology Department, Clinique Croix Du Sud, Quint-Fonsegrives, France.
Louise DuffautGRC n°20, Groupe de Recherche Clinique sur la Lithiase Urinaire, Hôpital Tenon, Sorbonne Université, Paris, France.
Frederic PanthierGRC n°20, Groupe de Recherche Clinique sur la Lithiase Urinaire, Hôpital Tenon, Sorbonne Université, Paris, France.
Yves AlloryDepartment of Pathology, Institut Curie, Université Paris Saclay, Saint-Cloud, France.
François AudenetDepartment of Urology, Hôpital Européen Georges-Pompidou AP-HP Centre, Université Paris Cité, Paris, France.
Priscilla LeonUrology Department, Clinique Pasteur, Royan, France.
Constance ThibaultMedical Oncology Department, Hôpital européen Georges-Pompidou AP-HP Centre, Université Paris Cité, Paris, France.
Morgan RouprêtSorbonne University, GRC 5 Predictive Onco-Uro, AP-HP, Urology, Hôpital Pitié-Salpetrière, Paris, France.
Mathieu RoumiguiéUrology Department, Clinique Pasteur, Toulouse, France.
Alexandra Masson-LecomteDepartment of Urology, Université de Paris, APHP, Saint Louis Hospital, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate the oncological and perioperative outcomes of robot-assisted bladder cuff excision (RA-BCE) versus open bladder cuff excision (O-BCE) after radical nephroureterectomy (RNU) for patients with upper tract urothelial carcinoma (UTUC). PATIENTS AND

methodsWe conducted a multicenter study including all consecutive patients who underwent RA-BCE or O-BCE in eight French academic institutions from 2014 to 2023. Kaplan-Meier curves were used to illustrate survival outcomes, while uni- and multivariable Cox regression analyses were conducted to identify independent predictors of survival by calculating hazard (HRs) ratios with their corresponding 95% confidence intervals (CIs).

resultsOverall, 487 patients underwent either RA-BCE (n = 182; 37.4%) or O-BCE (n = 305; 62.6%). The median follow up was 30.1 (26.9-36) months. Kaplan-Meier analyses showed that the use of RA-BCE versus O-BCE was associated with similar 3-year intravesical recurrence-free survival (RFS) (68.9% vs. 59.7%; p = 0.1), 3-year extravesical RFS (69.2 vs. 63.8%; p = 0.2), 3-year cancer-specific survival (CSS) (85.5% vs. 76.2%; p = 0.08), and 3-year overall survival (OS) (76% vs. 67.6%; p = 0.1). Multivariable Cox regression analyses confirmed that the use of RA-BCE versus O-BCE was associated with similar 3-year intravesical recurrence (HR 0.83; 95% CI 0.55-1.26; p = 0.4), as well as similar 3-year extravesical recurrence (p = 0.8), 3-year CSS (p = 0.3), and 3-year OS (p = 0.3). Among 340 patients (69.8%) assessed, RA-BCE was associated with a lower rate of overall 90-day complications (p = 0.02), fewer major complications (p = 0.02), and a shorter length of stay (p < 0.01).

conclusionsOur multicenter study supports the effectiveness of RA-BCE versus O-BCE in the treatment of UTUC with comparable 3-year oncological outcomes.

Indexed as

Carcinoma, Transitional CellNephroureterectomyRobotic Surgical ProceduresUreteral NeoplasmsUrinary BladderUrinary Bladder NeoplasmsAgedFemaleFollow-Up StudiesFranceHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesBladder cuff excisionDistal ureterOpenRadical nephroureterectomyRoboticUpper tract urothelial carcinoma

Identifiers

PMID42108360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.