ArticleMethods in molecular biology (Clifton, N.J.)2026
Measurement of T Cell Migration by T Cell-Dependent Bispecific Antibody in Cancer Cells and T Cell Cross-Linking.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
T cell-dependent bispecific antibodies (TDBs) have revolutionized the treatment of innovative cancer therapies with their potent anti-tumor effects, especially against hematologic malignancies. T cell responses to TDBs induce T cell migration, which is believed to play an important role in drug efficacy. Effective migration of T cells within the tumor microenvironment increases their contact with tumor cells and enhances T cell activation and cytotoxic activity against tumor cells. In this protocol, we present a method using TDB co-culture supernatants and a trans-well to evaluate T cell migration. This will provide a reliable approach to analyze in detail the mechanism of T cell migration in TDB-mediated immunotherapy and contribute to improving its drug efficacy.
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