Evidence map›Paper›PMID 42108296›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2026

Gut Microbial Metabolism in Colorectal Cancer.

Yaowei Qin, Zhen Feng, Zhonghua Cheng, Danfeng Wen, Jiufeng Li, Zuoyun Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaowei Qin *Shanghai Pudong Hospital and Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhen FengDepartment of Gastroenterology, Dahua Hospital of Xuhui District, Shanghai, China.
Zhonghua Cheng *Department of Gastroenterology, Shanghai Xuhui Center Hospital, Shanghai, China.
Danfeng Wen *Department of Environmental Health, School of Public Health, NHC Key Laboratory of Health Technology Assessment, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Jiufeng LiDepartment of Environmental Health, School of Public Health, NHC Key Laboratory of Health Technology Assessment, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Zuoyun WangShanghai Pudong Hospital and Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, China. wangzuoyun@fudan.edu.cn.ORCID https://orcid.org/0000-0003-4428-5477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut is colonized by a diverse array of microorganisms, including bacteria, fungi, viruses, and archaea. They produce various metabolites such as bile acids, tryptophan derivatives, fatty acids, and vitamins, which play crucial roles in maintaining gut homeostasis and are also associated with a variety of intestinal diseases, including colorectal cancer (CRC). CRC is one of the most common malignant tumors and the second leading cause of cancer-related death worldwide, with a high tendency to metastasize to distant organs such as the liver and lungs. Extensive research has demonstrated that gut microbiota and their metabolites influence colorectal carcinogenesis through multiple mechanisms. This review summarizes the mechanisms underlying the association between gut microbial metabolism and CRC and outlines the clinical translational prospects of gut microbiota and their metabolites, including their roles as biomarkers and therapeutic agents. Additionally, the gaps in current research and potential directions for future studies are identified and discussed.

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeAnimalsHumansCancer-associated fibroblastsColorectal cancerFecal immunochemical testGut microbial metabolismIntestinal microbiota

Identifiers

PMID42108296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.