Evidence map›Paper›PMID 42108286›Full record

ArticleNature communications2026

Geometry of the cumulant series in diffusion MRI.

Santiago Coelho, Jenny Chen, Filip Szczepankiewicz, Els Fieremans, Dmitry S Novikov

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Santiago CoelhoCenter for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, USA. Santiago.Coelho@nyulangone.org.ORCID 0000-0002-1039-4803
Jenny ChenCenter for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-8211-7346
Filip SzczepankiewiczDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID 0000-0002-5251-587X
Els FieremansCenter for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-1384-8591
Dmitry S NovikovCenter for Biomedical Imaging and Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, USA. Dmitry.Novikov@nyulangone.org.ORCID 0000-0002-4213-3050

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Christopher M Collins · 2014 to 2026
$19.3M
Mesoscopic Biomarkers of Neurodegeneration with Diffusion MRIR01NS088040 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2014 to 2023
$5.2M
Random Matrix Theory-Based Noise Removal in MRIR01EB027075 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2019 to 2022
$2.7M
Fast High-Resolution Microstructure Diffusion MRI Exploiting Data RedundancyK99EB036080 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COELHO, SANTIAGO · 2024 to 2025
$222k
Cancerfonden (Swedish Cancer Society) 22 0592 JIANIBIB NIH HHS K99 EB036080NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB027075NINDS NIH HHS R01 NS088040Vetenskapsrådet (Swedish Research Council) 2021-04844
6 · The paper itself

Abstract

Water diffusion gives rise to micron-scale sensitivity of diffusion MRI (dMRI) to cellular-level tissue structure. Precision medicine and quantitative imaging depend on uncovering the information content of dMRI and establishing its parsimonious hardware-independent fingerprint. Based on the rotational SO(3) symmetry, we study the geometry of the dMRI signal and the topology of its acquisition, identify irreducible components and a full set of invariants for the cumulant tensors, and relate them to tissue properties. Including all kurtosis invariants improves multiple sclerosis classification in a cohort of 1189 subjects. We design the shortest acquisitions based on icosahedral vertices to determine the most used invariants in only 1-2 minutes for whole brain. Representing dMRI via scalar invariant maps with definite symmetries will underpin machine learning classifiers of pathology, development, and aging, while fast protocols will enable translation of advanced dMRI into clinic.

Indexed as

BrainDiffusion Magnetic Resonance ImagingMultiple SclerosisAlgorithmsHumansImage Processing, Computer-Assisted

Identifiers

PMID42108286
PMCPMC13161373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.