ArticleExperimental eye research2026
PRCD-associated retinitis pigmentosa in dogs and humans.
Article in Experimental eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
PRCD is a ∼6 kDa protein localized to the cytosolic surface of rod and cone outer segment discs. Pathogenic variants in the PRCD gene cause autosomal recessive retinal degeneration in human patients and in over 65 dog breeds. We characterized the natural history and phenotype of PRCD-associated retinal disease in dogs and compared it with the human condition. Human patients with PRCD-associated retinitis pigmentosa, p.R22∗ variant, exhibited severe, retina-wide degeneration, abnormal electroretinograms, and constricted visual fields. However, visual acuity and foveal photoreceptor structure could be preserved into the second decade of life. In dogs, four homozygous mutants (p.Cys2Tyr variant, PRCD
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