ArticleThe Journal of biological chemistry2026
A high-sensitivity strategy to screen NAD(P)H-dependent reductase activity by coupled enzyme cascade.
Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Enzymes play a pivotal role in "green chemistry" as tools for biocatalysis. Oxidoreductase enzymes are especially useful for carrying out key electron transfer (redox) steps toward a wide range of chemical transformations (e.g., asymmetric hydrogenation, oxygenation, hydroxylation, epoxidation, or Baeyer-Villiger oxidation) that might not otherwise be available to chemists through conventional (nonbiological) synthetic approaches. The ability to screen oxidoreductase activity is important in identifying useful biocatalysts from nature, and also toward engineering novel ones through directed evolution. Many valuable redox enzymes are dependent upon NAD(P)H as an electron-donating co-substrate (or conversely, upon NAD(P)
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