ReviewRedox biology2026
Nitric oxide-releasing responsive biomaterials for antimicrobial skin therapy.
Review in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a key signaling molecule involved in many physiological processes including vasodilation, neurotransmission, inflammatory and antimicrobial responses. Despite its therapeutic potential, its clinical utility remains limited due to its extremely short half-life (less than 5 s), high reactivity (with oxygen radicals) and the need for precise spatiotemporal dose control. To overcome these limitations, recent advancements in biomaterials have led to the development of responsive systems capable of delivering NO in a targeted and controlled manner. These systems can respond to endogenous stimuli (such as pH changes, enzymatic activity, altered redox environment (associated with hypoxia, oxidative stress) which are key characteristics of diseased cells) or to exogenous stimuli (such as light, X-ray, ultrasound). By allowing site-specific and time-controlled NO release, these responsive biomaterials offer improved control over local NO delivery and are being evaluated predominantly in in vitro and animal models. In this review, we discuss the advances in design of NO-releasing responsive biomaterials with a particular focus on applications in antimicrobial skin therapy. This review bridges materials bioengineering and dermatology to explore the promise of NO-based therapies for tackling skin and wound care problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.