ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Skull Bone Marrow-to-Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression.
Lei Xiong, Dong Sun, Hao-Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen-Cheng Xiong
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Lei XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Dong SunDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Hao-Han GuoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Daehoon LeeDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Zhipeng LiuDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Lin MeiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Wen-Cheng XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Funding
LRP4 deficiency in Alzheimer's disease developmentRF1AG066526 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2020 to 2020
$2.8MSwedish APP mutation and NMJ decline in Alzheimer's diseaseRF1AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2020 to 2020
$2.6MSwedish APP mutation and NMJ decline in Alzheimer's diseaseR01AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2015 to 2024
$2.6MLRP4 deficiency in Alzheimer's disease developmentR01AG066526 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2024 to 2024
$708kNIA NIH HHS R01 AG051510NIA NIH HHS R01 AG066526NIA NIH HHS RF1 AG051510NIA NIH HHS RF1 AG066526NIH HHS AG051510NIH HHS AG066526
6 · The paper itselfAbstract
Patients with Alzheimer's disease (AD) often develop osteoporosis, but the role of bone remodeling in AD remains unclear. We previously showed that osteoblast-specific expression of APP
Indexed as
Alzheimer DiseaseBone MarrowBrainCerebrovascular CirculationCognitionMyeloid CellsOsteoblastsSkullAnimalsCell MovementDisease Models, AnimalDisease ProgressionHumansMiceMice, TransgenicAlzheimer's diseaseAPPATP6AP2dural channelsmeningesosteoblastsskull bone marrow
Identifiers
PMID42107073
PMCPMC13336015
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