ArticleThe Journal of frailty & aging2026
Declining kidney function and frailty progression: a 7-year cohort study of Chinese middle-aged and older adults.
Article in The Journal of frailty & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to investigate the association between baseline kidney function and frailty trajectories in middle-aged and older adults.
methodsData were derived from the China Health and Retirement Longitudinal Study (2011-2018), including 5364 participants aged ≥45 years at baseline with up to four assessment waves over approximately 7 years. Kidney function was evaluated using estimated glomerular filtration rate based on serum creatinine and cystatin C (eGFR
resultsAt baseline, the mean frailty index was higher in participants with mildly (β=2.28, 95% CI: 1.63-2.94) and moderately-to-severely (β=3.70, 95% CI: 2.41-4.99) reduced kidney function compared to normal kidney function, where β represents the adjusted difference in frailty index relative to the reference group. Frailty index increased over time in all groups; in participants with normal kidney function, it rose by 0.83 points per year (95% CI: 0.77-0.90). The annual increase was 0.26 points greater (95% CI: 0.18-0.35) in the mildly reduced and 0.70 points greater (95% CI: 0.54-0.87) in the moderately-to-severely reduced group. Over approximately 7 years, predicted mean frailty index increased from 15.1 to 20.9, 17.4 to 25.0, and 18.8 to 29.5 in the normal, mildly reduced and moderately-to-severely reduced groups, respectively.
conclusionsMiddle-aged and older adults with lower kidney function exhibited higher frailty index levels at baseline and faster frailty progression over time.
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