Evidence map›Paper›PMID 42107006›Full record

ArticleAlimentary pharmacology & therapeutics2026

Asian Patients Report Higher Reflux Symptom Burden than US Patients Despite Lower Objective Reflux Burden.

Walter W Chan, Ming-Wun Wong, Matthew K Schroeder, Allyson G Richardson, Chien-Lin Chen, C Prakash Gyawali

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Walter W ChanDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ming-Wun WongDepartment of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.
Matthew K SchroederDivision of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.
Allyson G RichardsonDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Chien-Lin ChenDepartment of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.ORCID https://orcid.org/0000-0002-9084-8210
C Prakash GyawaliDivision of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

Research Training in Gastrointestinal and Hepatic DiseasesT32DK135449 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Jessica R. Allegretti · 2023 to 2026
$1.7M
NIDDK NIH HHS T32 DK135449NIH HHS T32DK135449
6 · The paper itself

Abstract

backgroundSymptoms and reflux burden in gastroesophageal reflux disease (GERD) may vary between populations.

aimsTo evaluate relationships between symptom profiles and objective reflux burden in patients in two world regions, Asia and the United States.

methodsThis was a cross-sectional study of patients undergoing pH-impedance monitoring from one Asian and two US centres. Validated patient-reported symptom instruments were prospectively collected. Symptom characteristics were compared against objective reflux burden (acid exposure time, AET; total reflux episodes, TRE; mean nocturnal baseline impedance, MNBI) from pH-impedance monitoring between the two populations.

resultsOf 1099 patients, 162 were in Asia (age 47.4 ± 1.1 years, 36.4% female, body mass index, BMI 24.2 ± 0.4 kg/m

conclusionsCompared to US patients, GERD profiles in Asian patients associate with higher symptom reporting despite lower objective reflux burden.

Indexed as

Asian PeopleGastroesophageal RefluxAdultAsiaCross-Sectional StudiesEsophageal pH MonitoringFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexSymptom BurdenUnited Statesacid exposure timebaseline impedancegastroesophageal reflux diseaseglobal symptom severity

Identifiers

PMID42107006
PMCPMC13419094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.