ArticleVeterinary research2026
Mechanistic role of lipid metabolism in foot-and-mouth disease virus (FMDV) replication.
Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Foot-and-mouth disease (FMD) is a highly contagious animal disease caused by foot-and-mouth disease virus (FMDV), primarily affecting cloven-hoofed animals such as swine, cattle, and sheep. As a core metabolic pathway for maintaining cellular homeostasis, lipid metabolism is frequently hijacked by viruses via metabolic reprogramming mechanisms to support their infection cycle. Studies have demonstrated that positive-sense single-stranded RNA viruses can reshape the host cell membrane system and modulate the lipid metabolic network, thereby constructing a favorable microenvironment for their invasion and replication. However, the molecular mechanisms by which FMDV-also a positive-sense single-stranded RNA virus-promotes viral replication through the regulation of lipid metabolism remain incompletely elucidated. In this study, we found that inhibiting the key enzymes involved in the lipid metabolic pathway could significantly suppress FMDV proliferation. Exogenous supplementation of the downstream products catalyzed by these key enzymes notably restored FMDV replication, indicating that FMDV replication is dependent on lipids. Furthermore, we observed a significant upregulation in the protein expression of carnitine palmitoyltransferase 1A (CPT1A) in host cells following FMDV infection. Inhibition of this enzyme led to a marked reduction in FMDV replication, suggesting that FMDV may enhance the fatty acid β-oxidation pathway to supply energy for its replication. In conclusion, this study comprehensively verified the critical role of lipid metabolism in FMDV replication through multidimensional assays involving the administration of inhibitors targeting key enzymes in the lipid metabolic pathway. These findings provide novel theoretical insights for the development of antiviral drugs and the prevention and control of FMD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.