ArticleJournal of translational medicine2026
Functional heterogeneity of sperm binding to the ZP2 N terminus across normospermic and infertile phenotypes.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
backgroundHuman gamete recognition is mediated by the N-terminal domain of the zona pellucida protein ZP2. Conventional semen analysis often fails to identify functional subpopulations within heterogeneous ejaculates, particularly in men with defective spermiogenesis. This study sought to evaluate if a recombinant ZP2
methodsSperm samples from 10 normospermic and 12 infertile participants (oligozoospermia, asthenozoospermia, and teratozoospermia) were incubated with agarose beads conjugated to recombinant ZP2
resultsNormospermic individuals exhibited nearly four-fold inter-individual heterogeneity in ZP2 CONCLUSION(S): Recombinant ZP2
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