Trial reportBMC medicine2026
The therapeutic effect of novel endoscopic submucosal dissection with lymph node dissection surgery on T1 ESCC: A single center, prospective, and nested case-control study.
Trial report in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
Abstract
backgroundEndoscopic submucosal dissection is effective for treating T1 early esophageal squamous cell carcinoma. However, there is a risk of lymph node metastasis . Standard radical surgery may be overtreatment for T1 ESCC. This trial was designed to clarify the efficacy of novel dual-scopy combined surgery in the treatment of T1 ESCC.
methodsBetween December 2021 and May 2025, 21 patients underwent dual-scopy combined surgery, 197 underwent ESD, and 213 underwent radical surgery for early (T1 stage) ESCC. This study included 63 patients who underwent ESD, dual-scopy combined surgery, and standard radical surgery (1:1:1) in the efficacy analysis. The patients' overall survival, recurrence-free survival, disease-specific survival, complications, and clinical outcomes were evaluated.
resultsThere was no significant difference among the three groups in OS, RFS, and DSS. Complication rates were similar between the ESD and dual-scopy groups, both lower than in the radical surgery group. Compared to the radical surgery group, the ESD and dual-scopy groups demonstrated significantly shorter hospital stays and lower costs. Postoperative quality of life and nutritional levels were better in both the ESD and dual-scopy groups compared to radical surgery.
conclusionsFor T1-stage ESCC patients without clear metastasis, the novel dual-scopy combined surgery may achieve lesion resection and lymph node dissection without affecting patient survival. Moreover, it may reduce postoperative complications, hospitalization time, and costs, and potentially improve quality of life and nutritional status compared to standard radical surgery.
trial registrationThis study was registered as a clinical trial with the China Clinical Trial Registration Center (ChiCTR2100053603).
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