ArticleArchives of public health = Archives belges de sante publique2026
Effect of PM2.5 exposure on the risk of incident autoimmune diseases: a prospective cohort study in Taiwan.
Article in Archives of public health = Archives belges de sante publique, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe interaction between fine particulate matter (PM2.5) and genetic factors is thought to play a significant role in the development of autoimmune diseases. However, the impact of PM2.5 exposure on the onset of these diseases remains unclear. This population-based cohort study investigated the effect of year-to-year variations in PM2.5 exposure levels on incident autoimmune disease risk in Taiwanese adults.
methodsIn this longitudinal study, we followed-up 276,254 adults from the Taiwan MJ cohort (2005-2017) for 9.3 years to identify incident autoimmune diseases cases, ascertained from the patients' clinical and laboratory reports. Autoimmune diseases were categorized as systemic and organ-specific. Data on residential address-specific annual PM2.5 concentrations were obtained from Taiwan Air Quality-Monitoring sites. A time-dependent Cox regression model, considering death as a competing risk, was used to assess the effect of year-to-year variations in PM2.5 exposure levels on autoimmune disease risk.
resultsDuring the 2,579,362 person-years of follow-up, new-onset autoimmune diseases were observed in 958 (0.35%) individuals, corresponding to an incident density of 37.14 per 100,000 person-years. Participants with high PM2.5 exposure levels (per 5-µg/m
conclusionsProactive air pollution control strategies are crucial for the prevention of autoimmune diseases, particularly SLE and Sjögren's syndrome.
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