ArticleJournal of nanobiotechnology2026
Modular assembly of nanocomposite hydrogel with NIR-responsive black phosphorus release and mild photothermal synergy for enhanced regenerative microenvironment and accelerated infectious bone repair.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Infectious bone defects remain a clinical challenge due to the lack of spatiotemporal control over bacterial infection, immune microenvironment modulation, vascular regeneration, and osteogenic differentiation. Herein, we engineered a modularly assembled 808 nm near-infrared (NIR)-responsive therapeutic system with three functional modules, including a 3D-printed honeycomb-mimetic poly(lactic acid) (HP) framework as a mechanically supportive module, collagen-graphene oxide-black phosphorus (CGB) nanocomposite hydrogel as an ECM-mimetic filling module, and NIR-responsive black phosphorus (BP)-release module. Under NIR-induced mild photothermal effects, CGB@HP hydrogel exhibited NIR-responsive BP-release, BP's degradation into PO
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