Evidence map›Paper›PMID 42106684›Full record

Observational studyBMC psychiatry2026

The effort of maintaining the defensive wall: is there a link between defense mechanisms and vitality?

Anja Vandersmissen, Patrick Fissler Plischke, Marco Filippi, Maya Wenzel, Maren Bernhardt, Rainer Krähenmann

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05544877 (An Energetic View on Creativity, Psychopathology and Intelligence), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05544877 nacompletednot on this map

An Energetic View on Creativity, Psychopathology and Intelligence: A Mixed Design Study in Adults With and Without Psychological Disorders

TypeinterventionalSponsorPsychiatrische Dienste ThurgauRan2022 to 2023Enrolled200ConditionsGeneral Psychopathology, Fatigue, Depressive Disorder, MajorArmsIntegrated 5-day Gratitude Exercise and Behavioral Activation Program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anja VandersmissenPsychiatric Services Thurgau (Academic Teaching Hospital of the University of Konstanz), Spital Thurgau AG, Seeblickstrasse 3, Münsterlingen, 8596, Switzerland. anja.vandersmissen@uzh.ch.ORCID 0000-0002-6873-4743
Patrick Fissler PlischkePsychiatric Services Thurgau (Academic Teaching Hospital of the University of Konstanz), Spital Thurgau AG, Seeblickstrasse 3, Münsterlingen, 8596, Switzerland.
Marco FilippiPsychiatric Services Thurgau (Academic Teaching Hospital of the University of Konstanz), Spital Thurgau AG, Seeblickstrasse 3, Münsterlingen, 8596, Switzerland.
Maya WenzelPsychiatric Services Thurgau (Academic Teaching Hospital of the University of Konstanz), Spital Thurgau AG, Seeblickstrasse 3, Münsterlingen, 8596, Switzerland.
Maren BernhardtPsychiatric Services Thurgau (Academic Teaching Hospital of the University of Konstanz), Spital Thurgau AG, Seeblickstrasse 3, Münsterlingen, 8596, Switzerland.
Rainer KrähenmannPsychiatric Services Thurgau (Academic Teaching Hospital of the University of Konstanz), Spital Thurgau AG, Seeblickstrasse 3, Münsterlingen, 8596, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitality - the sensation of energy availability and lack of fatigue - is a transdiagnostic factor playing a role in various psychiatric disorders. Defense mechanisms are strategies individuals use to deal with internal or external stress and can be categorized by their degree of adaptiveness, summarized as defensive maturity. Immature defense mechanisms involve awareness inhibition, which is assumed to be an energy-demanding process contributing to reduced vitality. In this study, we examine whether defense mechanisms are associated with vitality.

methodsA transdiagnostic sample of 200 participants (100 with and 100 without psychiatric disorders) was analyzed in a cross-sectional design. Defensive maturity and mature and immature defense mechanisms were assessed using the Defense Mechanisms Rating Scale-Self-Report-30. Vitality was measured using the vigor and fatigue subscales of the Profile of Mood States.

resultsIn line with our hypotheses, defensive maturity and immature defense mechanisms were associated with vitality (r = .31, p < .001 and r = - .27, p < .001, respectively), even after adjusting for sleep quality (β = 0.20, p = .004 and β = - 0.16, p = .023, respectively). Additional analyses that accounted for both mature and immature mechanisms revealed that only immature defense mechanisms (β = - 0.32, p < .001), but not mature (β = - 0.07, p = .356), predicted vitality.

conclusionsOur results show that primarily immature defense mechanisms are related to impaired vitality. This is in line with the assumption that inhibiting thoughts or emotions is an energy-demanding process. Alternatively, a lack of energy availability may impair defense maturity. Targeting immature defense mechanisms in psychotherapeutic interventions may improve vitality as a transdiagnostic factor in a variety of psychiatric disorders in which fatigue is an accompanying symptom.

trial registrationThe study was registered on 2022-07-30 on https://clinicaltrials.gov/ (identifier: NCT05544877).

Indexed as

Adaptation, PsychologicalDefense MechanismsFatigueMental DisordersAdultCross-Sectional StudiesFemaleHumansMaleRandomized Controlled Trials as TopicYoung AdultCopingDefense mechanismsDMRS-SR-30Psychological distressVitality

Identifiers

PMID42106684
PMCPMC13292504

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.