ArticleBMC plant biology2026
Exometabolomic-enabled discovery of compounds associated with Escherichia coli O157:H7 population dynamics in the lettuce phyllosphere.
Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundContamination of fresh produce with human pathogens remains a serious public health and economic concern due to the absence of effective kill steps in the farm-to-fork chain. Escherichia coli O157:H7 has been implicated in multiple illness outbreaks linked to lettuce.
resultsWe examined the exometabolomic profile of 31 lettuce genotypes and identified variations in the chemical composition of both the leaf surface and the leaf apoplast, supporting variable bacterial growth. Furthermore, inoculation with E. coli O157:H7 induced changes in the overall chemistry of these leaf niches, allowing the identification of many niche-specific differentially accumulated metabolites (DAMs). Intersection analysis revealed little overlap of DAMs among the genotypes, suggesting that multiple metabolites, or a combination of metabolites, may contribute to bacterial persistence in phyllosphere niches. This information guided the design of metabolite cocktails to supplement bacterial inoculations of leaves. Overall, we observed that inhibitory and promoting cocktails significantly shifted the bacterial population titer to lower and higher, respectively, when compared to the control without metabolite supplementation. These shifts were more pronounced in some lettuce genotypes than others.
conclusionsThese findings provide new insights into how the phyllosphere chemistry influences the survival of E. coli O157:H7, offering potential targets to mitigate food safety concerns through genetic and metabolic engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.