Evidence map›Paper›PMID 42106499›Full record

ArticleSpine deformity2026

The impact of osteoporosis on preoperative presentation in adult spinal deformity patients undergoing surgical correction: a retrospective study.

Kyriakos D Chatzis, Anthony N Baumann, Max Fisher, Oluwatobi Onafowokan, Mohammad Daher, Peter Tretiakov, Francesca Totis, Ethan Cottrill, Drew Millar, Emmanuelle Ferrero and 4 more

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Article in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Kyriakos D ChatzisDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Anthony N BaumannDepartment of Orthopaedics, Cleveland Clinic Akron General, Akron, OH, USA.
Max FisherDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Oluwatobi OnafowokanDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Mohammad DaherDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Peter TretiakovDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Francesca TotisDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Ethan CottrillDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Drew MillarDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA.
Emmanuelle FerreroOrthopaedic Surgery Department, Hôpital Européen Georges Pompidou, Paris, France.
Marc KhaliféOrthopaedic Surgery Department, Hôpital Européen Georges Pompidou, Paris, France.
Rafael De La Garza RamosDepartment of Neurosurgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Andrew J SchoenfeldDepartment of Orthopedic Surgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Peter G PassiasDepartment of Neurological and Orthopaedic Surgery, Duke University, Durham, NC, USA. pgpassias@yahoo.com.ORCID http://orcid.org/0000-0002-1479-4070

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOsteoporosis is common in adults with spinal deformity (ASD) and may worsen baseline malalignment and disability. Because these conditions often coexist, understanding how osteoporosis and patients meeting criteria for high risk of osteoporosis affect deformity severity and quality of life is key to improving outcomes.

methodsAdults (≥ 18 years) undergoing ASD surgery with complete baseline and two-year follow-up data were stratified into osteoporosis, high-risk, and non-osteoporotic cohorts. Osteoporosis was defined by preexisting diagnosis; high-risk by American Association of Clinical Endocrinologists (AACE) criteria (female ≥ 65 years or risk factors: steroids, chronic kidney disease, alcohol use, vitamin D deficiency, limited mobility, diabetes). Non-osteoporotic patients had normal bone quality. Baseline alignment was evaluated using Global Alignment and Proportionality (GAP) and Sagittal Age-Adjusted Score (SAAS). Health-related quality of life (HRQoL) was analyzed using multivariable regression adjusted for age, BMI, Charlson Comorbidity Index (CCI), and modified Fragility Index (mFI).

resultsAmong 899 patients (mean age 60.3 ± 15.0 years; 74% female; BMI 27.5 ± 5.8 kg/m

conclusionASD patients with osteoporosis or high-risk features exhibit poorer quality of life and more severe deformity at baseline, as inadequate bone health remains independently associated with worse radiographic alignment and greater disability after adjustment for confounders.

Indexed as

Adult spinal deformity (ASD)Bone healthFrailtyOsteoporosisQuality of lifeSagittal alignment

Identifiers

PMID42106499

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