Evidence map›Paper›PMID 42106478›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

PET imaging of FAAH in chronic Cannabis users: longitudinal assessment during short-term abstinence.

Claudia Poluga, Shahtaj S Dheda, Nadia Boachie, Tina McCluskey, Lucas Narciso, Maia Zilberman, Cassie Côté, Marilyn A Huestis, Rachel F Tyndale, Stefan Kloiber and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Quantification of [Frontiers in neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Claudia PolugaBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Shahtaj S DhedaBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Nadia BoachieBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Tina McCluskeyBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-6795-4808
Lucas NarcisoBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Maia ZilbermanBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Cassie CôtéBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0009-0003-4350-6618
Marilyn A HuestisInstitute for Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2137-4645
Rachel F TyndaleBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Stefan KloiberDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-6838-4114
Nathan J KollaBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Pablo M RusjanDepartment of Psychiatry, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0075-2918
Bernard Le FollBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-6406-4973
Jerry J WarshDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Tony P GeorgeBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1645-9767
Isabelle BoileauBrain Health Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. isabelle.boileau@camh.ca.ORCID http://orcid.org/0000-0002-9901-1484

Funding

Understanding Cannabis Withdrawal: A PET Study of Endocannabinoid MetabolismR21DA045296 · NIDA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI BOILEAU, ISABELLE · 2018 to 2019
$295k
Canada Research Chairs (Chaires de recherche du Canada) 202004CRCNIDA NIH HHS R21 DA045296
6 · The paper itself

Abstract

Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments. The endocannabinoid enzyme fatty acid amide hydrolase (FAAH) may influence cannabis use and withdrawal, but the relationship between FAAH levels and withdrawal symptoms remains unclear. This study aims to investigate changes in FAAH levels during short-term abstinence from cannabis and their relationship with withdrawal symptoms. FAAH levels were measured in whole-brain regions of interest using positron emission tomography (PET) with the FAAH-specific probe [

Indexed as

AmidohydrolasesBrainMarijuana AbuseSubstance Withdrawal SyndromeAdultBenzamidesCarbamatesFatty Acid Amide HydrolasesFemaleHumansLongitudinal StudiesMalePositron-Emission TomographyYoung AdultAmidohydrolasesBenzamidesCarbamatescyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl esterFatty Acid Amide Hydrolases

Identifiers

PMID42106478
PMCPMC13598130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.