Inhibition of a live-attenuated chlamydia oral vaccine in the large intestine is dependent on CD11c-expressing cells that produce IL-23.

Ying He, Ahmed Mohamed Abdelsalam, Yi Wu, Mariah Rodroguez, Huizhou Fan, Guangming Zhong

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying HeDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

Ahmed Mohamed AbdelsalamDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

Yi WuDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

Mariah RodroguezDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

Huizhou FanDepartment of Physiology, Robert Wood Johnson Medical School Research Tower, 675 Hoes Lane, Room 400, Piscataway, NJ, 08854, USA.

Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA. Zhongg@UTHSCSA.EDU.

Funding

An oral vaccine against Chlamydia trachomatisU01AI182210 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUANGMING ZHONG · 2024 to 2026

$6.5M

NIAID NIH HHS U01 AI182210NIH HHS U01AI182210

6 · The paper itself

Abstract

The live-attenuated oral vaccine intrOv is an IFNγ-susceptible mutant of C. muridarum that is rapidly cleared from the large intestine by IFNγ-producing group 3 innate lymphoid cells (IFNγ

Indexed as

Bacterial VaccinesChlamydia InfectionsChlamydia muridarumInterleukin-23Intestine, LargeAdministration, OralAnimalsCD11 AntigensDendritic CellsInterferon-gammaInterleukin-23 Subunit p19MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicVaccines, AttenuatedBacterial VaccinesCD11 AntigensInterferon-gammaInterleukin-23Interleukin-23 Subunit p19Itgax protein, mouseVaccines, AttenuatedBone marrow-derived dendritic cellsChlamydia oral vaccineIL-23IntrOvLarge intestine

Identifiers

PMID42106471

DOI10.1038/s41598-026-51625-5

PMCPMC13346799

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.