Evidence map›Paper›PMID 42106460›Full record

ArticleNPJ digital medicine2026

Digital health interventions for psychological outcomes among adolescents and young adults with cancer: a systematic review and meta-analysis.

Panpan Xiao, Yihui Wei, Yan Kate Chow, Keary Rui Zhou, Winnie Wan-Yee Tso, Kevin Yi-Lwern Yap, Herbert Ho-Fung Loong, Chi Kong Li, Yin Ting Cheung

Abstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exploring young adult cancer survivors' perspectives on generative AI chatbots for symptom support.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Panpan XiaoSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yihui WeiSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yan Kate ChowSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Keary Rui ZhouSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Winnie Wan-Yee TsoDepartment of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
Kevin Yi-Lwern YapAlice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Herbert Ho-Fung LoongDepartment of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chi Kong LiDepartment of Paediatrics & Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong SAR, China.
Yin Ting CheungSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. yinting.cheung@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescents and young adults (AYAs) with cancer show a strong interest in digital health interventions (DHIs); however, limited pooled evidence from randomized controlled trials (RCTs) exists regarding their quantitative benefits in this population. This systematic review and meta-analysis (PROSPERO: CRD42024593656) screened a total of 9949 records from six databases, registers and other sources up to January 5, 2025, and included 31 articles from 25 studies examining DHIs targeting psychological outcomes among AYAs. Most DHIs were conducted via websites (n = 13), mobile applications (n = 5), wearable devices (n = 6), or videoconferencing/telephone (n = 6), and interventions were multicomponent and promoted self-management. Meta-analysis showed a significant effect of DHIs on quality of life, anxiety, psychological distress, and social support. Meta-regression revealed that the mode of delivery (instructor-based vs. self-guided) moderated the effects of DHIs on anxiety and depressive symptoms, with instructor-based DHIs producing significantly stronger effects. Future RCTs evaluating the impact of DHIs on cognitive impairment and cost-effectiveness are needed.

Identifiers

PMID42106460
PMCPMC13612578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.