ArticleScientific reports2026
Construction of a quantitative extracellular pH map of rat brain glioma using CEST-MRI with iobitridol as the contrast agent.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
This study aimed to evaluate whether chemical exchange saturation transfer (CEST) imaging, in combination with the nonionic X-ray iodinated contrast agent Iobitridol, can detect extracellular pH (pHe) in rats with gliomas and enable the construction of quantitative pHe maps. CEST pH imaging was performed both on Iobitridol phantoms and on rat models bearing brain gliomas, using a 7.0 Tesla small animal MRI scanner (Agilent Technologies) and employing varying radiofrequency (RF) powers (1.5, 3.0, and 6.0 µT) based on the ratio of apparent exchange-dependent relaxation (AREX
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