Evidence map›Paper›PMID 42106417›Full record

ArticleScientific reports2026

Effects of voltage-gated sodium channels on the median effective dose of ropivacaine in diabetic rats.

Xueyin Song, Kang Lv, Peixia Yu, Xiang Liu, Yaozong Yu, Gaoya Cao, Yanlei Tai, Bo Zhao, Qiujun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xueyin SongDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China.
Kang LvDepartment of Neurosurgery, Hebei General Hospital, NO.348, Heping West Road, Shijia Zhuang, Hebei Province, China.
Peixia YuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China.
Xiang LiuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China.
Yaozong YuDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China.
Gaoya CaoDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China.
Yanlei TaiDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China.
Bo ZhaoExperimental Center for Teaching, Hebei Medical University, No.361, Zhongshan East Road, Shijia Zhuang, Hebei, China. zhaobo@hebmu.edu.cn.
Qiujun WangDepartment of Anesthesiology, Hebei Medical University Third Hospital, Hebei Provincial Key Laboratory of Precision Anesthesia and Organ Protection, NO.139, Ziqiang Road, Shijia Zhuang, Hebei Province, China. 37000628@hebmu.edu.cn.

Funding

Natural Science Foundation of Hebei Province H2024206055the Central Government-Guided Local Science and Technology Development Fund 246Z7702Gthe Medical science research project of hebei 20250589
6 · The paper itself

Abstract

Diabetes mellitus significantly impacts perioperative anesthetic management. Patients with diabetic neuropathy exhibit increased sensitivity to local anesthetics, yet the underlying mechanisms, particularly regarding the median effective dose (ED

Indexed as

Anesthetics, LocalDiabetes Mellitus, ExperimentalDiabetic NeuropathiesRopivacaineVoltage-Gated Sodium ChannelsAnimalsDose-Response Relationship, DrugGanglia, SpinalMaleNerve Conduction StudiesNeural ConductionRatsRats, Sprague-DawleySciatic NerveAnesthetics, LocalRopivacaineVoltage-Gated Sodium ChannelsDiabetes mellitusDiabetic neuropathyMedian effective doseRopivacaineVoltage-gated sodium channels

Identifiers

PMID42106417
PMCPMC13347050

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.