Design, synthesis, and insecticidal potency of novel 3-methyl-pyrazole derivatives against Culex pipiens larvae.

Hager R Nofal, Ali Khalil Ali, Mahmoud F Ismail, Mahmoud Kamal, Eslam M Hosni, Eslam M Abbass

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hager R NofalChemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Ali Khalil AliChemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Mahmoud F IsmailChemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Mahmoud KamalEntomology Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Eslam M HosniEntomology Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Eslam M AbbassChemistry Department, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt. eslammorad@sci.asu.edu.eg.ORCID 0000-0002-3245-1653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mosquito-borne illnesses remain a serious public health concern worldwide, with the growing resistance of vectors such as Culex pipiens reducing the efficacy of standard insecticides. In pursuit of alternative control strategies, a new library of 3-methyl-pyrazole derivatives was rationally designed, synthesized through multistep reactions, and comprehensively characterized using IR, NMR, and mass spectrometry. Larvicidal screening of all nineteen synthesized 2-methyl-pyrazole derivatives, conducted according to WHO protocols, revealed several highly active candidates. Among these, derivatives 7 and 12 exhibited the most potent activity, with LC

Indexed as

CulexInsecticidesPyrazolesAcetylcholinesteraseAnimalsCholinesterase InhibitorsDrug DesignLarvaMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAcetylcholinesteraseCholinesterase InhibitorsInsecticidesPyrazoles3-Methyl-pyrazoleAcetylcholinesterase inhibitionCulex pipiensLarvicidal activityMolecular dockingMosquito controlSAR

Identifiers

PMID42106391

DOI10.1038/s41598-026-50895-3

PMCPMC13157491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.