Evidence map›Paper›PMID 42106325›Full record

ArticleNature communications2026

Oral delivery of enterocyte-mimetic butyrate-loaded nanoparticles repairs the gut barrier and inhibits growth of digestive system tumors.

Guocheng Xie, Zhenzhen Fu, Yifan Zhang, Ziqiang Xu, Kaikai Xue, Huijuan Dai, Feng Wu, Sisi Lin, Jinyao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guocheng Xie *Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhenzhen Fu *Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yifan ZhangShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ziqiang XuShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Kaikai XueShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Huijuan DaiDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Feng WuShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wufeng199001@163.com.
Sisi LinShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. sisilin@shsmu.edu.cn.ORCID http://orcid.org/0000-0003-2027-8993
Jinyao LiuShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. jyliu@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-6044-2033

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22425505
6 · The paper itself

Abstract

Pathogenesis, progression, and therapeutic response of numerous digestive system tumors are associated with reduced intestinal barrier integrity. Here, we find that oral delivery of enterocyte-mimicking butyrate-loaded nanoparticles (EMBNs) capable of repairing the gut barrier can inhibit the occurrence, growth, and metastasis of digestive system tumors. EMBNs are prepared via loading butyrate into electrostatically complexed and sodium triphosphate-stabilized chitosan/hyaluronic acid nanoparticles, which are further coated with cell membranes extracted from enterocytes. The presented membrane receptors adsorb lipopolysaccharide and zonulin, known promoters of intestinal barrier impairment, while the loaded butyrate strengthens the function of the intestinal barrier. Mechanistically, the inhibition of autophagy in enterocytes and the promotion of a healthy microbial composition contribute to the repair of the gut barrier. Oral ingestion of EMBNs suppresses the disturbance of the liver immune microenvironment via alleviating the disruption of the intestinal barrier, achieving potent inhibition against hepatocellular carcinoma and hepatic metastasis of colonic carcinoma in dextran sulfate sodium-induced model in male mice. The reinforcement of the gut barrier spotlights a strategy to prevent and treat digestive system tumors.

Indexed as

ButyratesEnterocytesNanoparticlesAdministration, OralAnimalsAutophagyCell Line, TumorChitosanDextran SulfateHumansHyaluronic AcidIntestinal Barrier FunctionIntestinal MucosaMaleMiceButyratesChitosanDextran SulfateHyaluronic Acid

Identifiers

PMID42106325
PMCPMC13376569

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.