Evidence map›Paper›PMID 42106173›Full record

ReviewHandbook of clinical neurology2026

Decoding the roles of bipolar, amacrine, and horizontal cells.

Abdul Rhman Hassan, Jeremy M Bohl, Tomomi Ichinose

Abstract readReview
In one paragraph

Review in Handbook of clinical neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abdul Rhman HassanDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, United States.
Jeremy M BohlDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, United States.
Tomomi IchinoseDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, United States.

Funding

Mechanisms of Motion Detection in Retinal Neural NetworkR01EY028915 · NEI · WAYNE STATE UNIVERSITY · PI Tomomi Ichinose · 2018 to 2026
$3.8M
ON and OFF visual signaling in the retinal interneuronsR01EY032917 · NEI · WAYNE STATE UNIVERSITY · PI ICHINOSE, TOMOMI · 2021 to 2025
$1.9M
NEI NIH HHS R01 EY028915NEI NIH HHS R01 EY032917
6 · The paper itself

Abstract

The retina consists of several specialized cell types, crucial for visual processing. Bipolar cells, amacrine cells, and horizontal cells are retinal interneurons, playing pivotal roles in transmitting and modulating visual information within the retina. In this chapter, we first highlight the significance of bipolar cells in relaying signals from photoreceptors to ganglion cells, initiating visual signaling. Recent consensus indicates the existence of different types of bipolar cells in various species, leading us to focus on their functional diversity and morphologic characteristics. Second, we explore many types of amacrine cells and their roles in lateral inhibition, modulating signaling between bipolar cells and ganglion cells. Lastly, we examine the structure and function of horizontal cells in providing feedback inhibition to cones, regulating light sensitivity and color processing. Structural analysis of retinal neurons over the decades has revealed that complicated retinal neural networks are the crucial component for signal processing in the visual system. Such insights are essential for understanding the mechanisms underlying visual perception and pathology, developing future therapies for retinal diseases, and advancing artificial vision technologies.

Indexed as

Amacrine CellsRetinaRetinal Bipolar CellsRetinal Horizontal CellsAnimalsHumansVisual PathwaysAmacrine cellBipolar cellFeedbackHorizontal cellInhibitionNeural networkRibbon synapse

Identifiers

PMID42106173
PMCPMC13248563

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.