Evidence map›Paper›PMID 42106055›Full record

ArticleJournal of molecular and cellular cardiology2026

Loss of phospholamban phosphorylation blunts Ca

Achal M Gowda, Holden T Rogers, Erick B Ríos Pérez, Daniela Ponce-Balbuena, Samuel L Shenkenberg, Ying Ge, Francisco J Alvarado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Achal M GowdaDepartment of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Holden T RogersDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Erick B Ríos PérezDepartment of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Daniela Ponce-BalbuenaDepartment of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Samuel L ShenkenbergDepartment of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ying GeDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA; Human Proteomics Program, University of Wisconsin School of Medicine and Public Health. Madison, WI, USA.
Francisco J AlvaradoDepartment of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: falvarad@medicine.wisc.edu.

Funding

Deciphering Myofilament Modifications in Ischemic CardiomyopathyR01HL109810 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GE, YING · 2013 to 2024
$3.5M
Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasR01HL167195 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado, Hector H Valdivia · 2023 to 2026
$2.4M
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathyR01HL161070 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado · 2022 to 2026
$1.9M
Role of Cardiac Proteoform Alterations in the Pathogenesis of Phospholamban R14del CardiomyopathyF31HL178305 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ROGERS, HOLDEN TYLER · 2025 to 2025
$38k
NHLBI NIH HHS F31 HL178305NHLBI NIH HHS R01 HL109810NHLBI NIH HHS R01 HL161070NHLBI NIH HHS R01 HL167195
6 · The paper itself

Abstract

Adrenergic stimulation modulates excitation-contraction coupling (ECC) and cardiac function primarily through protein kinase A (PKA), which phosphorylates multiple ECC proteins. Key PKA targets include phospholamban (PLB), a critical regulator of SERCA2-mediated Ca

Indexed as

Adrenergic AgentsCalciumCalcium-Binding ProteinsAnimalsCalcium SignalingCyclic AMP-Dependent Protein KinasesExcitation Contraction CouplingMiceMyocytes, CardiacPhospholambanPhosphorylationSarcoplasmic ReticulumAdrenergic AgentsCalciumCalcium-Binding ProteinsCyclic AMP-Dependent Protein KinasesPhospholambanAdrenergic responseCalcium signalingExcitation-contraction couplingPhospholambanSarcoplasmic reticulum

Identifiers

PMID42106055
PMCPMC13202633

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.